IMPUTING AMINO ACID POLYMORPHISMS IN HUMAN LEUKOCYTE ANTIGENS.

Imputing amino acid polymorphisms in human leukocyte antigens.

DNA sequence variation within human leukocyte antigen (HLA) genes mediate susceptibility to a wide range of human diseases.The complex genetic structure of the major histocompatibility complex (MHC) makes it difficult, however, to collect genotyping data in large cohorts.Long-range linkage disequilibrium between HLA loci and SNP markers across the

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