Imputing amino acid polymorphisms in human leukocyte antigens.
DNA sequence variation within human leukocyte antigen (HLA) genes mediate susceptibility to a wide range of human diseases.The complex genetic structure of the major histocompatibility complex (MHC) makes it difficult, however, to collect genotyping data in large cohorts.Long-range linkage disequilibrium between HLA loci and SNP markers across the